The 26-year-old player, who transferred from Atalanta to Juventus in August for a fee of up to 60.7 million euros ($66.4 million), may be sidelined for up to four weeks due to an injury.
That would rule him out of Juve's trip to fierce rivals and reigning Serie A champions Inter Milan later this month.
Koopmeiners' layoff is the latest to hit coach Thiago Motta, who last week lost key defender Gleison Bremer to an anterior cruciate ligament injury which could keep the Brazil defender out for the rest of the season.
Also on Juve's treatment table are wingers Nicolas Gonzalez and Timothy Weah and striker Arkadiusz Milik, who has had persistent problems with his left knee.
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Juventus are third in Serie A, three points behind league leaders Napoli and level with their next opponents Lazio.
(Except for the headline, this story has not been edited by staff and is published from a syndicated feed.)
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