The forward is fully fit to play, but is currently being limited by a toe injury.
The Sweden striker has been struggling with the problem this season and was unable to score in their 1-0 loss to Brighton.
Howe stated: "I think there are reasons for that. Any kind of injury breaks momentum and I think to expect Alex to have been at his very best today... (would be asking a lot).
"Of course, yes he trained in the build-up to the game, but he hadn't had the depth of training he probably needs for full performance. But I thought a lot of his game was very good today. I have no major issues and I thought he played very well out of possession for us.
"Anthony (Gordon), I thought, led the line really well in that respect. I think if he had scored two goals, no-one could have complained and we'd be having a different conversation, so they are such fine margins for any player."